Nomee collects many social networks, allowing you to focus on following people instead of websites. It tracks a huge number of social networks. Nomee does not cater to any one social network extensively, including Twitter. Still, it seemed appropriate to write up its actual tweeting abilities for those curious about using this social dashboard.
DestroyTwitter is a full-featured yet lightweight Adobe AIR twitter app. While many other AIR apps are guilty of being on the pudgy and/or sluggish side, DestroyTwitter is refreshingly responsive. Upon load it starts at about 40MB and after using it for a bit, searching, and loading a couple other columns it only climbed to 61MB. Very good for an AIR app!
Even though the memory footprint is light, it doesn't skimp on features. The app is maintained by Jonnie Hallman, an Experience Designer at Adobe, so that may have something to do with it.
ada is a compact twitter client running on Adobe AIR. The interface is very minimal and the basic feature set is tucked away by default and revealed when you hover over a tweet. RT, reply, and favorite buttons appear on the right side of each tweet. Otherwise, the interface is similar to an IM window. In the lower left of the window there is a filter box for usernames. Typing just a few letters of any username you follow will give you a list of their recent tweets.
Twhirl is an Adobe AIR app, so it runs on both Macs and PCs. It can connect to multiple social networks, including Twitter, Friendfeed, identi.ca, or seesmic (who created this software). It receives regular updates and is adding new features with each update. Some of the features include:
TweetDeck is an Adobe AIR Twitter app for power users. Using a column layout, TweetDeck allows a user to set up many feeds at once. Some are specialized to Twitter, such as your friends, @ mentions, direct messages and so forth. But the real power lies in their numerous advanced search features, which filter the public timeline any way you desire: