Nomee collects many social networks, allowing you to focus on following people instead of websites. It tracks a huge number of social networks. Nomee does not cater to any one social network extensively, including Twitter. Still, it seemed appropriate to write up its actual tweeting abilities for those curious about using this social dashboard.
Nambu is a feature-rich Twitter app for Mac OS X that supports many social networks. It offers plenty of configuration options but has simple defaults for beginners. It also has excellent integration with its sister services, tr.im and pic.im
Tweetings is a small, secure Twitter client for Windows. It has a compact interface that scoots out of the way when you minimize to the system tray.
TweetDeck is a feature-stuffed multi-column Twitter app for the iPhone. It is already a major desktop twitter client, running on Adobe AIR, with all the features anyone could ask for (including multiple accounts as of 0.26), so it seemed like they would spend all their time making a great user interface. They packed it all in there, but at the expense of usability. From their website:
Selective Twitter Status is a Facebook Application that lets you decide when to post Twitter updates to Facebook by including a #fb hashtag at the end of your tweet. Many Facebook users get confused or annoyed by the volume of status information a regular tweeter broadcasts. Running this app allows both parties to remain happy instead of endlessly insulting the other faction with wild, emotional attachment to their platform of choice.
This Facebook app cannot work if your updates are protected. It has no password integration.
From digsby.com:
digsby is a multiprotocol IM client that lets you chat with all your friends on AIM, MSN, Yahoo, ICQ, Google Talk, and Jabber with one simple to manage buddy list. digsby also has a social networking tool that alerts you of events like new messages and gives you a live Newsfeed of what your friends are up to.
TweetDeck is an Adobe AIR Twitter app for power users. Using a column layout, TweetDeck allows a user to set up many feeds at once. Some are specialized to Twitter, such as your friends, @ mentions, direct messages and so forth. But the real power lies in their numerous advanced search features, which filter the public timeline any way you desire: